CHEM-V10 PRE-STATISTIC FREEZE MANIFEST

freeze_artifact_commit=b051a9a0f6939af469b26026e9d98cad20f95eac
v10_hypothesis_statistics_computed_at_freeze=0
v10_evaluation_runs_at_freeze=0
protocol_tests_passed=27
independent_target_free_code_audit=no_blocker

DISCLOSURE
status=post-reveal, pre-statistic, target-independent mechanical repair
target_file_extracted_before_v10=1
target_rows_displayed_before_v10_freeze=2
displayed_rows_sort_order=reaction_id
displayed_yields=0,0
target_distribution_inspected=0
descriptor_target_association_inspected=0
hypothesis_statistic_inspected=0

LINEAGE
chem_v9_freeze_commit=bfb3bdbb0c4c63daf7f530df5522bdd46ffd7a10
chem_v9_manifest_commit=0b1049488f12cfbdc23b0935b185dde29040de85
chem_v9_integrity_result_commit=967deca87a9bea7879b9bfe1eb10b3dcfe1383fe
chem_v9_evaluator_sha256=731fc7078ad306d6a363d4cd2b844dc4fb7721009cb72f0e289c784a55133729
chem_v9_decision=INCONCLUSIVE
chem_v9_failure=global slot-union guard demanded training coverage for unused anomalous slot 48

PRESERVED TARGET ARTIFACT
path=research/chemistry/validation/chem_v9/results/chem_v9_targets.tsv
rows_including_header=49633
target_rows=49632
sha256=58dae5feac0aad193b3a8d6590120b5abfea02447aed093e4b146ccaf9a8f407

SOLE ANALYTICAL CHANGE
For each held-out primary experiment, construct LOEO scores only for coded ligand slots used by its frozen eligible primary panel. Rank all 47 rows in every training block, including anomalous L106. No row, structure, block, experiment, descriptor, baseline, null, statistic, threshold, seed, or decision gate changes.

TARGET-FREE PREFLIGHT
loaded_memberships=49632
unique_loaded_reaction_ids=49632
loaded_blocks=1056
unique_rows_per_loaded_block=47
primary_blocks=864
primary_experiments=14
required_missing_total=0
minimum_training_rows_per_required_slot=991
globally_observed_slots=1-48
required_slot_union=1-47
globally_observed_but_not_required=48
slot_48_rows=1
slot_48_source_experiment=XZ-01-1
slot_48_required_by_primary_panel=0
anomalous_block=00ab912e0eff6a901dbc3314af67dd92b65640918126f7036976b4f64a90b0c8
anomalous_block_missing_standard_slot=16
anomalous_block_extra_slot=48
preflight_pass=1

V10 FILE SHA256
CHEM-V10-Preregistration.md=67a772fbd601fc303ba6539d9a730599d991d2a8112fbcf8f23153cab748a49d
README.md=2c986cc90ed14434e6fc45139df78509e1735831c45f71523be349ef12516e86
chem_v10_evaluate.py=bebe13f046a689f440e483e25956a0489203f66e5c8e076be2cddeef59a42473
frozen/required_slot_preflight.json=9a88e79f12d9ea1adfe559bd8d80104ae5dcac582337e5bb6059fb48a136ebd3
requirements.txt=28d471a63d5a1d5ca4d62a5b7d9ad0150335121605eca435fd5d1b6ae8963863
test_chem_v10_evaluate.py=c5378749514cf08fa3a0e468f8af12256ce0446fe9200baedf2efd7bfc70c2ea

FREEZE COMMANDS
uv run --with-requirements research/chemistry/validation/chem_v10/requirements.txt python research/chemistry/validation/chem_v10/chem_v10_evaluate.py preflight research/chemistry/validation/chem_v9/frozen research/chemistry/validation/chem_v10/frozen/required_slot_preflight.json
uv run --with-requirements research/chemistry/validation/chem_v10/requirements.txt python -m unittest -v research/chemistry/validation/chem_v10/test_chem_v10_evaluate.py research/chemistry/validation/chem_v9/test_chem_v9_prepare.py research/chemistry/validation/chem_v9/test_chem_v9_evaluate.py

ONE-SHOT POST-FREEZE COMMAND
uv run --with-requirements research/chemistry/validation/chem_v10/requirements.txt python research/chemistry/validation/chem_v10/chem_v10_evaluate.py evaluate research/chemistry/validation/chem_v9/frozen research/chemistry/validation/chem_v9/results/chem_v9_targets.tsv research/chemistry/validation/chem_v10/results/CHEM-V10-Result.json

CLAIM BOUNDARY
A pass is post-reveal repaired corroboration of a scoped observational, context-sensitive association stronger than the frozen molecular and stable-position controls in these ORD panels. It is not pristine confirmation, independent replication, causality, a thermodynamic equation of state, a physical law, or physical circuitry. Plate randomization is undocumented and exact inference moves only 19 of 45 structures.
